Brian Sandford, Sr.'s wife has now been identified (Isabella Blackburn of Yorkshire), and I'm currently working with two wills from her family (his in-laws) in order to get him properly connected with the rest of his family. Or at least as much as possible. The name "Edmund" is also associated with this Yorkshire Brian, as I'd already suspected based on the feets of fines I reviewed recently. But I have a feeling the name Edmund was repeated often in the Sandford family, so I'm sure there is more work ahead after this.
"The family of Sandford ended during the reign of Elizabeth, in the three daughters and coheirs of Hercy Sandford, Esq. For these I must refer my readers to the History of South Yorkshire, i. 310. Brian Sandford was probably the first of his name who came from Westmerland into Yorkshire. This change of residence was in all probability caused by his marriage."