Private User,
R' Moshe Heilprin (Maharsha father-in-law) appears to have been a great grandfather of R' Isaac Halpern, A.B.D. Tykocin. This is what I meant when I said that the same woman (Esther) could not have been married to both men.
Following the link from the Esther #2 profile https://www.jewishgen.org/webtrees/individual.php?pid=I1116&ged...
the interactive chart for David Halpern's ancestors provides a nice visual depiction of how Moshe's father Zevulon was the same generation as the Meir of Padua.
It also shows us that just as R' Isaac Halpern, A.B.D. Tykocin was a great-grandson of Zevulons son R' Moshe Heilprin (Maharsha father-in-law), Jacob Shor was a great grandson of the Meir of Padua's son Samuel Yehuda. And we can see that the daughter of Jacob Shor (3rd great grand-child of the Meir of Padua) married Rabbi Eliezer Lippman Heilprin, A.B.D. of Tarnogrod (3rd great grandson of Rabbi Zevulun Eliezer Heilprin)
Now, as you can see R' Moshe's Halprin lineage does not connect up with the Katzenellenbogen line of descent until the marriage of his 2nd great grandson to the daughter of Jacob Shor (who was a 2nd great granddaughter of Samuel Yehuda Katzenellenbogen. Consequently, the focus in UC is on the descendants of Jacob Shor's daughter and her husband R' Eliezer, although her Eliezer's father R' Isaac of Tykocin happens to be mentioned, and there is a footnote next to his name which refers us to sources for more information on Halperin family Ancestry:
footnote #64 from page 24 of Volume 3-
For the Halperin family see MLGO, 70, AEA and Horowitz, LTKP, 406. See also the memorial book on Stanislaw, with a Halpern family tree and the Pinsk-Karlin memorial book article by Z Rabinowitz of Haifa (Luria and Halpern families). For Isaiah his son, see LTKP, 530. Published sources list his children. Other sources have a rabbi-son who was ABD Klimontow (as opposed to Kreszow) and a rabbi-son, ABD Sikva while omitting a son Simon (information from a Lvov document, a copy of which is in possession of DovBerish Weber).
I don't entirely understand all of the abbreviations in the footnote, and maybe I need to figure them out. In any case, I hope having this extra information will be helpful to you.
Claudia