Conan O'Brien is Stanley Ann Dunham's (Barack OBama's mother) first cousin 10 times removed's husband's 8th great niece's husband.
Conan O'Brien is George Washington, 1st President of the USA's second cousin once removed's wife's first cousin 6 times removed's husband.
Queen Elizabeth II is Conan O'Brien's wife's first cousin four times removed's husband's first cousin's husband's second cousin twice removed.
Sarah, Duchess of York is Conan O'Brien's wife's third cousin four times removed's husband's fourth great niece.
Conan O'Brien is John F. Kennedy, 35th President of the USA's brother-in-law's sister's husband's father's wife's third great uncle's wife's fourth great niece's husband.
Heinrich III, Holy Roman Emperor is Conan O'Brien's wife's 8th great grandmother's husband's daughter's husband's 11th great grandfather.
Saint John Paul II is Conan O'Brien's wife's fourth great uncle's wife's great grandfather's wife's first cousin 6 times removed's ex-husband's fourth cousin once removed.
Pope Paul III is Conan O'Brien's wife's 6th great aunt's husband's 6th great grandmother's ex-partner's daughter's husband's grandfather.
Muirchertach macNéill macLochlainn King of Cenél is Conan O'Brien's wife's first cousin four times removed's husband's first cousin's husband's 15th great grandfather.
Robert III, King of Scots is Conan O'Brien's wife's 6th great aunt's husband's 10th great grandfather.
Áed Sláine High King of Ireland, High King of Ireland is Conan O'Brien's wife's 8th great grandmother's husband's daughter's husband's 25th great grandfather.
Cennetig mac Lorcain, King of the Dal gCais is Conan O'Brien's wife's 8th great grandmother's husband's daughter's husband's 12th great grandfather.
Sechnussach, High King of Ireland is Conan O'Brien's wife's 8th great grandmother's husband's daughter's husband's 23rd great grandfather.
Niall of the Nine Hostages, King of the Connachta is Conan O'Brien's wife's 8th great grandmother's husband's daughter's husband's 28th great grandfather.
Morough O'Brien, King of Leinster is Conan O'Brien's wife's 7th great aunt's husband's wife's 20th great grandfather.
James FitzMaurice FitzGerald, 10th Earl of Desmond is Conan O'Brien's wife's fourth great aunt's husband's wife's 10th great grandfather.
Sir Lucius Henry O'Brien, 3rd Baronet O'Brien is Conan O'Brien's wife's first cousin 6 times removed's husband's brother's wife's fourth cousin's husband.
Barnabas O'Brien, 5th Earl of Thomond is Conan O'Brien's wife's 8th great grandfather's wife's first cousin four times removed's husband.
F. Scott Fitzgerald is Conan O'Brien's wife's first cousin 6 times removed's husband's second cousin four times removed's husband.
Ronald W. Reagan, 40th President of the USA is Conan O'Brien's wife's second cousin 8 times removed's wife's son's wife's fourth great niece's 2nd husband.
Tip O'Neill, 55th Speaker of the U.S. House of Representatives is Conan O'Brien's wife's 8th great aunt's husband's first cousin 8 times removed's husband.
Jackie Gleason is Conan O'Brien's wife's fourth cousin four times removed's wife's second cousin thrice removed.
Grace Kelly is Conan O'Brien's wife's third cousin four times removed's wife's second cousin four times removed's 1st wife.
William Bingham, U.S. Senator is Conan O'Brien's wife's first cousin 6 times removed's husband.
Stephen Colbert is Conan O'Brien's wife's third cousin 6 times removed's husband's fifth great niece's husband.
It seems Conan O'Brien's wife has all the connections.